Evaluate the liver function in hyperthyroidism patients

Thyroid hormones regulate the metabolisms of all cells including hepatocytes, and hence, modulate hepatic function. Hyperthyroidism is one of the most common endocrine disorders characterized by increased secretion of thyroid hormones T3 and/or T4. This study investigated frequency of abnormal liver function tests in the patients with hyperthyroidism that referred to Imam Reza Hospital of Kermanshah from 1[st] October 2009 to 30[th] April 2012. Patients who had complication disorders such as cardiovascular disease, hypertension, diabetes mellitus, liver disease and using any of drugs effecting liver and thyroid function tests and patients with positive hepatic viral markers were excluded from the study. After excluding patients with complication disorders, fifty patients were remained. Fifty volunteers without history of significant diseases were chosen as matched control group. Mean ALT [Alanine amino transferase] of cases were 52.1+/-6.97 and of controls were 25.6+/-3.9. Also, Mean ALP [Alkaline phosphatase] of cases was 259.94+/-25.83 and of controls were 185.10+/-33.75. There is significant difference between ALT, ALP in case group in compare the control group [P<0.05and P<0.01 respectively]. Further, there is no significant difference in serum levels of AST [Aspartate amino transferase] and Mean direct bilirubin between case and control group. These findings indicate that ALT and ALP levels are frequently elevated in hyperthyroidism. Hence, they are possibly thyroid dependent enzymes

Relationship between the pattern of coronary artery disease risk factors and lipid ratios with five groups of body mass index in 28566 healthy adults

Pattern of the coronary artery disease [CAD] risk factors across body mass index [BMI] categories remains uncertain. There is a different threshold of obesity for increasing cardiovascular hazard across populations, accordingly recognition and management of obesity and overweight can guide better control of CAD epidemic in the national level. To determine the discrepancy in the prevalence of CAD risk factors across five BMI categories. A population based survey of 28566 participants recruited to medical screening of taxi drivres in Tehran [MSTDT] was designed. According to a standardized protocol data on CAD risk factors were obtained by taking medical history, examination and laboratory tests. After adjustment for age, sex, literacy, smoking, systolic blood pressure [SBP], fasting blood sugar [FBS], and LDL-C/HDL-C ratio, these CAD risk factors of diastolic blood pressure [DBP]>90 mmHg, hypertriglyceridemia, high triglyceride/HDL-C ratio, hypercholesterolemia, and high cholesterol/HDL-C ratio were increased significantly across five incremental categories of BMI. Prevalence of DBP>90 mmHg, hypertriglyceridemia, hyper cholesterolemia and ratios of cholesterol/HDL-C and TG/HDL-C increased considerably across five groups of BMI. This pattern is different from previous research and our results endorsed more features of pattern of CAD risk factors across BMI categories

Bloodless correction. a case report

This report describes a 74 year old woman with urinary symptoms progressing to complete anuria with dense labial adhesions. This condition is mostly reported in pediatric age group but few reports addressed this condition in postmenopause

[ effect of vaginal Misoprostol and intravenous Oxytocin for labor induction]

Unripe cervix is one of the most causes of failure of labor induction. There are different methods for labor induction, which may differ depending on its duration. This study was performed to compare the effectiveness of vaginal Misoprostol intravenous and Oxytocin for induction of labor on hospitalized patients. In a randomized clinical trail 110 pregnant women with Bishop score<6 requiring induction of labor were divided into two groups. The first group [n=50] received 25 g vaginal Misoprostol and dosage was repeated every 4 hours until reach to either onset of the active labor or the final dose of 100 g. Second group [n=60] received intravenous Oxytocin started from 2.66 mu/min and up to the maximum dose of 42.5 mu/min or until the onset of the active labor. Inductions to delivery time interval, maternal and neonatal outcomes were recorded. Statistical analysis was performed using the U Mann-Whitney and Chi Squared tests. After matching mother age, gestational age, Bishop score, gravidity and parity, sample size decreases to 48 cases in Misoprostol group and 54 cases in Oxytocin group. There was no significant difference in the mean time from induction to delivery between Misoprostol and Oxytocin groups [10.16+3.66 vs. 8.86+3.65 and P=0.121]. The rate of cesarean was 18.8% and 25.9% in Misoprostal and Oxytocin groups, respectively [P=0.387]. This study showed that the maternal and neonatal outcomes of induction were not significantly different in two groups. It seems that vaginal Misoprostol could be administrated for the induction of labor